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eventDeadline: Mar 05 publicUnited States redeemFree

The NIDDK Disorders of Gastrointestinal Interoception Consortium (DGIC) - Clinical Research Centers (U01 Clinical Trial Not Allowed)

National Institutes of Health

This Notice of Funding Opportunity (NOFO) invites new applications to participate in the Diseases of Gastrointestinal Interoception Consortium (DGIC). The overall objectives of this consortium are to: 1) identify the underlying mechanisms that link altered GI interception more directly to GI dysmotility and symptoms; 2) identify disease or response biomarkers that better assess pathophysiology or treatment efficacy; and 3) leverage state-of-the-art technologies to identify novel therapeutic targets that could be assessed in future clinical trials. This NOFO uses a cooperative agreement mechanism (U01) and runs in parallel with a companion NOFO ( RFA-DK-28-214) .

eventDeadline: Mar 05 publicUnited States redeemFree

The NIDDK Disorders of Gastrointestinal Interoception Consortium (DGIC) Scientific Data Research Center (U24 Clinical Trial Not Allowed)

National Institutes of Health

This Notice of Funding Opportunity (NOFO) invites new applications to participate in the Diseases of Gastrointestinal Interoception Consortium (DGIC). The overall objectives of this consortium are to: 1) identify the underlying mechanisms that link altered GI interception more directly to GI dysmotility and symptoms; 2) identify disease or response biomarkers that better assess pathophysiology or treatment efficacy; and 3) leverage state-of-the-art technologies to identify novel therapeutic targets that could be assessed in future clinical trials.

eventDeadline: Feb 01 publicUnited States redeemFree

George M. O’Brien Urology Cooperative Research Centers Program (U54 Clinical Trial Optional)

National Institutes of Health

This Notice of Funding Opportunity (NOFO) seeks support for continuation of the NIDDK George M. O'Brien Urology Cooperative Research Centers (U54). The Urology Cooperative Research Centers foster impactful, multi-disciplinary research through collaborations within and outside the Centers and serve as a national resource for the urology research community.

eventDeadline: Nov 16 publicUnited States redeemFree

Assay Validation of High Quality Markers for Clinical Studies in Cancer (UH2/UH3 Clinical Trial Not Allowed)

National Institutes of Health

The purpose of the Notice of Funding Opportunity (NOFO) is to support the analytical and clinical validation of molecular, cellular, and imaging biomarkers and assays for cancer detection, diagnosis, prognosis, monitoring, prediction of response or resistance to treatment, cancer prevention and control, as well as pharmacodynamic markers and markers of toxicity. Utilizing either a phased UH2/UH3 or a standalone UH3 mechanism, funding will facilitate laboratory optimization and clinical validation of assays that work on human samples and address a clearly defined cancer-related clinical need within a well-specified intended use.

eventDeadline: Oct 10 publicUnited States redeemFree

Genomic and Biologic Therapies for ADRD (U01 Clinical Trial Optional)

National Institutes of Health

This Notice of Funding Opportunity (NOFO) supports the translation of genome editing and other biologic therapies for Alzheimer's Disease-Related Dementias (ADRD). The program spans the full translational pipeline, from therapeutic lead optimization and drug product development through IND-enabling studies and early clinical evaluation. Supported activities may include optimization of editing constructs and delivery systems; assessment of bioactivity, target engagement, durability, pharmacokinetics, and bioavailability; demonstration of in vivo efficacy; execution of safety pharmacology and toxicology studies; and development of scalable manufacturing processes, formulation strategies, and quality attributes aligned with regulatory expectations. ADRD include Frontotemporal Dementia (FTD); Lewy Body Dementias (LBD), including Dementia with Lewy Bodies (DLB) and Parkinson's Disease Dementia (PDD); Vascular Contributions to Cognitive Impairment and Dementia (VCID); and Multiple Etiology Dementias (MED).

eventDeadline: Feb 17 publicUnited States redeemFree

Research on System Support and Tools for Provider Training and Quality Monitoring for Suicide Preventive Care (RP1- Clinical Trial Optional)

National Institutes of Health

This notice of funding opportunity (NOFO) encourages research focused on developing, optimizing, and testing the effectiveness of service-ready, scalable strategies and tools that can be used to facilitate training (i.e., promote competence and sustained implementation fidelity) and quality monitoring in the delivery of evidence-based suicide prevention interventions across the range of settings where at-risk individuals are encountered, and across intercepts in suicide prevention services. Relevant research focuses on (1) developing and testing scalable approaches, including technology-supported approaches, for training providers in evidence-based approaches for assessing and managing risk (e.g., prevention, treatment, and crisis services), and/or (2) developing and validating pragmatic strategies for monitoring the delivery and quality of suicide prevention services, to facilitate efforts at training, supervision, and quality improvement efforts. In an effort to streamline the application process and sustain momentum in this critical research area, this NOFO supports both exploratory/developmental and standard research projects through a grant award instrument.

eventDeadline: Feb 20 publicUnited States redeemFree

NCI Research Specialist (Clinician Scientist) Award (R50 Clinical Trial Not Allowed)

National Institutes of Health

Through this notice of funding opportunity (NOFO), the National Cancer Institute (NCI) invites applications for the Research Specialist Award (R50) specifically for clinician scientists supporting NCI-funded clinical trials research. The Research Specialist Award is designed to encourage the development of stable research career opportunities for exceptional clinician scientists who want to continue to participate in the NCI clinical trials networks through leadership in the 1) development of national clinical trials, 2) implementation of NCI clinical trials in their institutions, and 3) national service to the NCI clinical trials networks through participation in the scientific review committees, monitoring committees and other activities, but not serve as principal investigators of research project grants. These clinician scientists are vital to sustaining the NCI-funded clinical trials enterprise. The Research Specialist Award is intended to provide salary support and sufficient autonomy so that individuals are not solely dependent on NCI grants held by others or other sources of support for cancer research career continuity.

eventDeadline: Dec 02 publicUnited States redeemFree

Nov 02

Cooperative Agreement for affiliated Partner with the Great Lakes Northern Forrest Cooperative Ecosystem Studies Unit

Geological Survey

The USGS is offering a funding opportunity to a CESU partner for research in improving accuracy assessment and area estimation for use in annual remote-sensing based land-cover monitoring. The Earth Resources Observation and Science (EROS) Center is a remotely sensed data management, systems development, and science center for the U.S. Geological Survey's (USGS) National Land Imaging Program. The USGS EROS has long been at the forefront of land cover research at local to global geographies. The USGS is modernizing its land cover monitoring capabilities and is enabling artificial intelligence, machine learning, and modeling for the detection of land change and the characterization of land cover at any time in the Landsat satellite record. The USGS is offering a funding opportunity to a CESU partner for research centered on improvements in land cover research by focusing on investigating and implementing state-of-the-art sampling and statistical strategies for accuracy assessment and area estimation, and the impacts of reference data uncertainties. This will be critical for characterizing the validity of USGS land cover change products such as the Annual National Land Cover Database (NLCD) which is used by other federal agencies, agencies of State, tribal, and local governments, institutes of higher education, and the private sector.

eventDeadline: Dec 23 publicUnited States redeemFree

Nov 02

Cooperative Agreement for affiliated Partner with the Californian Cooperative Ecosystem Studies Unit

Geological Survey

The USGS is offering a funding opportunity to a CESU partner for research in carbon cycling in seabed mineral environments. Seabed minerals may contain economically significant concentrations of valuable metals and rare earth elements which are essential to transportation, technological products, and defense and national security applications (i.e., critical minerals; Energy Act, 2020; U.S. Geological Survey, 2025; Hein et al., 2013, 2020). Of particular interest are manganese nodule fields throughout the abyssal Pacific Ocean, including in some U.S. EEZs, which have garnered attention over recent decades as potential areas for deep-sea mineral mining. Still, much more research is needed to understand the environmental settings where these minerals occur, how they form, and potential implications of extraction. This is crucial information for EO 14241 , 14285 , 14272 and SO 3417 . Carbon cycling is a key component of baseline environmental conditions within offshore resource systems. Sedimentary organic carbon is the primary food source at the base of deep sea food webs, and disturbance from marine mining could significantly alter carbon cycles and decrease benthic microbial and faunal activity. Benthic and midwater plumes generated by marine mining activities may further impact carbon cycling and biologic activity. From a mineral resource assessment perspective, sedimentary organic carbon plays a key role in manganese nodule formation and metal enrichment, though the carbon content, composition, and mechanisms to influence nodule formation remain unknown. The role of organic carbon in metal preservation for sediment covered seafloor massive sulfide systems is also a frontier science question. Sedimentary organic carbon can also be altered to oil or gas by high temperatures and/or pressures below the seafloor, sometimes co-occurring with seabed minerals at hydrothermal systems. Understanding these processes informs OCSLA 1953 & 1978 , and SO 3418 . Despite this importance, carbon cycling in marine mineral systems has received little attention, and fundamental science questions remain regarding how organic carbon cycling varies globally among nodule fields with differing sediment organic carbon content.